منابع مشابه
Systems biology meets platelet biology.
tion was associated with an observable survival benefit and delay in progression to AIDS among HIV-1–infected IDUs. 3 While HTLV-I has been definitively proven to cause adult T-cell leukemia/lym-phoma and a progressive neurodegenerative illness known as tropical spastic parapare-sis/HTLV-I–associated myelopathy (TSP/ HAM), a causal role for HTLV-II with either leukemia or TSP/HAM is much less w...
متن کاملSystems biology meets behavior.
E arly scientists were drawn to the study of insects in part because of the marvelous notion that their full behavioral repertoire was orchestrated from within. This was stated most succinctly perhaps by Spalding (1873): “When, as by a miracle, the lovely butterfly bursts from the chrysalis fullwinged and perfect, . . .it has, for the most part, nothing to learn, because its little life flows f...
متن کاملStem cell biology meets systems biology.
Stem cells and their descendents are the building blocks of life. How stem cell populations guarantee their maintenance and/or self-renewal, and how individual stem cells decide to transit from one cell stage to another to generate different cell types are long-standing and fascinating questions in the field. Here, we review the discussions that took place at a recent EMBO conference in Cambrid...
متن کاملSystems biology meets chromatin function
Introduction It is clear that DNA sequence and transcription factor availability alone are not sufficient for effective gene regulation in eukaryotes. Epigenetic factors at various levels also have an essential role: for example, DNA methylation and histone modifications form the molecular basis of gene regulation by creating chromatin microenvironments that promote or prevent transcription. Ge...
متن کاملMathematical modeling: epidemiology meets systems biology.
This issue of Cancer Epidemiology, Biomarkers, and Prevention includes a study on mathematical modeling of biological processes. Sokhansanj and Wilson describe a mathematical model that mimics the kinetics of base excision repair and thus permits them to investigate in silico the effects of genetic variation in this important DNA repair pathway (1). Why should epidemiologists have interest in t...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2009
ISSN: 1465-6906
DOI: 10.1186/gb-2009-10-8-313